The twain shall meet: channels, transporters and things between

The twain shall meet: channels, transporters and things between. Meeting on Membrane Transport in Flux: the Ambiguous Interface Between Channels and Pumps.

Introduction For many years, studies of ion channels and transport proteins have bred distinct fields with divergent approaches, mindsets and methods. ‘ion channelologists’ focused on gating and permeation, and mumbled about obscure kinetic schemes, whereas ‘transporterologists’ studied substrate coupling and transport kinetics, and mumbled about other obscure kinetic schemes. practitioners of ...

Direct arylation and heterogeneous catalysis; ever the twain shall meet

The formation of aryl-aryl bonds and heteroaryl analogues is one of the most important C-C bond forming processes in organic chemistry. Recently, a methodology termed Direct Arylation (DA) has emerged as an attractive alternative to traditional cross-coupling reactions (Suzuki-Miyaura, Stille, Negishi, etc.). A parallel focus of the pharmaceutical and other chemical industries has been on the u...

Tuberculosis and Nanotechnology: Where shall the Twain meet?

Tuberculosis remains among the commonest infectious diseases in the developing world and is a major source of morbidity and mortality. Conventional treatments typically consist of long-term therapy with multiple drugs which often leads to poor patient compliance as well as adverse effects. Poor compliance is in turn a major cause for the development of multidrug resistant (MDR) tuberculosis for...

"Never the twain shall meet": spirituality or psychotherapy?

Sivapithecus is east and Dryopithecus is west, and never the twain shall meet

Sivapithecus and Dryopithecus are well-described Miocene hominids (great apes and humans), both known since the 19th century. Over the years these genera have been combined into one (Dryopithecus) or separated up to the subfamily level. Each have been dismissed as interesting side branches, hailed as direct ancestors, or recognized as sister clades to one or more clade of extant hominid. Here I...